PolySciTech (
www.polyscitech.com) provides a wide
array of PEG-PLA block copolymers in our polyvivo line. Recently similar polymers have been
investigated for delivery of drugs across the blood-brain-barrier as a
treatment for alzheimer’s disease. Read more: Yao, Lei, Qingxiang Song, Wenkun
Bai, Jizhen Zhang, Deyu Miao, Mengyin Jiang, Yu Wang et al. "Facilitated
brain delivery of poly (ethylene glycol)–poly (lactic acid) nanoparticles by
microbubble-enhanced unfocused ultrasound." Biomaterials (2014).
http://www.sciencedirect.com/science/article/pii/S0142961213015275
“Abstract: Nanotechnology plays a unique
instrumental role in the revolutionary development of brain-specific drug
delivery, imaging, and diagnosis, but is highly limited by the existence of
blood–brain barrier (BBB). In this study, microbubble-enhanced unfocused
ultrasound (MEUUS) was developed as an approach to mediate an extensive brain
delivery of poly (ethylene glycol) – poly (lactic acid) (PEG–PLA) nanoparticles.
Following the MEUUS treatment, the nanoparticles signals were found to
penetrate through the vascular walls and distributed deeply into the parenchyma
at a significantly higher level (more than 250%) than those of the non-MEUUS
treated control. Such effect was reversible and dependent on nanoparticles
injection timing, sonication mode and mechanical index. Together with the
transmission electron microscopy analysis, the increased brain accumulation of
nanoparticles was claimed to be largely mediated by an ultrasound-induced
stable cavitation of the microbubble which resulted in mechanical stretching of
the vessel wall and consequently induced cellular transcytosis of the
nanoparticles. The MEUUS technique was also used to facilitate the brain delivery
of PEG–PLA nanoparticles functionalized with amyloid beta-specific antibody
6E10 for enabling the recognition of the hallmarks of Alzheimer's disease that
widely distributed in the brain. No erythrocytes extravasation and other
visible damages in the brain were detected following the MEUUS treatment. These
findings together indicated that unfocused ultrasound with the aid of
microbubble could effectively improve the brain delivery of nanoparticles, and
this approach might serve as a safe and flexible platform for the potential
application of nanoparticles in the diagnosis and therapy of brain diseases. Keywords:
Brain delivery; Nanoparticles; Microbubble; Unfocused ultrasound”
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