PolyScitech (
www.polyscitech.com) provides several
PLGA-PEG-PLGA thermogelling triblock copolymers (AK12, AK19, AK88). Recently
PolySciTech triblock thermogel was utilized by University of Wisconsin to
deliver paclitaxel, 17-AAG, and rapamycin simultaneously in a controlled manner
after injection to form a gel depot. In
mouse model this lead to reduced tumor volume and improved survival times. Read
more: Cho, Hyunah, and Glen S. Kwon. "Thermosensitive poly-(d,
l-lactide-co-glycolide)-block-poly (ethylene glycol)-block-poly-(d,
l-lactide-co-glycolide) hydrogels for multi-drug delivery." Journal of
Drug Targeting 0 (2014): 1-9. http://informahealthcare.com/doi/abs/10.3109/1061186X.2014.931406
“Abstract: A current treatment strategy for
peritoneal ovarian cancer is a combination of peritoneal surgery and
multi-drug-based chemotherapy that often involves intraperitoneal (IP)
injection. A thermosensitive
poly-(d,l-lactide-co-glycolide)-block-poly(ethylene
glycol)-block-poly-(d,l-lactide-co-glycolide) (PLGA-b-PEG-b-PLGA) hydrogel
platform (thermogels) enabled gel loading of poorly work-soluble paclitaxel
(cytotoxic agent), 17-allylamino-17-demethoxygeldanamycin (17-AAG, heat shock
protein inhibitor), and rapamycin (mammalian target of rapamycin protein
inhibitor). PLGA-b-PEG-b-PLGA thermogels (15%) carrying paclitaxel, 17-AAG, and
rapamycin (named Triogel) made a successful transition from a free-flowing
solution below ambient temperature to a gel depot at body temperature. Triogel
gradually released paclitaxel, 17-AAG, and rapamycin at an equal release rate
in response to the physical gel erosion. In an ES-2-luc ovarian cancer
xenograft model, a single IP injection of Triogel (60, 60, and 30 mg/kg of
paclitaxel, 17-AAG, and rapamycin, respectively) significantly reduced tumor
burden and prolonged survival of ES-2-luc-bearing nude mice without notable
systemic toxicity relative to those delivered by poly(ethylene
glycol)-block-poly(d,l-lactic acid) (PEG-b-PLA) micelles in solution via IP or
intravenous (IV) injection route. These results show a great potential of a
biodegradable thermogel platform carrying multi-drugs for IP chemotherapy in
peritoneal ovarian cancer. Keywords: 17-AAG, multi-drug delivery, ovarian
cancer, paclitaxel, PLGA-b-PEG-b-PLGA, raamycin, regel”
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