PolySciTech (
www.polyscitech.com) division of Akina
provides a wide array of polymer products. However there are other aspects to
the research which goes on at Akina and one of the products to come out of this
is the spinswiper which is a novel method for scale-up production of
microparticles using hydrogel template technology. This was the focus of a recent Purdue
Research Park press release. Read more here: http://purdueresearchpark.com/news/polyscitechs-spinswiper-could-speed-production-controlled-release-microparticles
Also read about some of the recent
research using the hydrogel template technology here: Acharya, Ghanashyam,
Crystal S. Shin, Matthew McDermott, Himanshu Mishra, Haesun Park, Ick Chan
Kwon, and Kinam Park. "The hydrogel template method for fabrication of
homogeneous nano/microparticles." Journal of Controlled Release 141, no. 3
(2010): 314-319. http://www.sciencedirect.com/science/article/pii/S0168365909007019
“Abstract: Nano/microparticles have been used
widely in drug delivery applications. The majority of the particles are
prepared by the conventional emulsion methods, which tend to result in
particles with heterogeneous size distribution with sub-optimal drug loading and
release properties. Recently, microfabrication methods have been used to make
nano/microparticles with a monodisperse size distribution. The existing methods
utilize solid templates for making particles, and the collection of individual
particles after preparation has not been easy. The new hydrogel template
approach was developed to make the particle preparation process simple and
fast. The hydrogel template approach is based on the unique properties of
physical gels that can undergo sol–gel phase transition upon changes in
environmental conditions. The phase reversible hydrogels, however, are in
general mechanically too weak to be treated as a solid material. It was
unexpectedly found that gelatin hydrogels could be made to possess various
properties necessary for microfabrication of nano/microparticles in large
quantities. The size of the particles can be adjusted from 200 nm to > 50
µm, providing flexibility in controlling the size in drug delivery
formulations. The simplicity in processing makes the hydrogel template method
useful for scale-up manufacturing of particles. The drug loading capacity is
50% or higher, and yet the initial burst release is minimal. The hydrogel
template approach presents a new strategy of preparing nano/microparticles of predefined
size and shape with homogeneous size distribution for drug delivery
applications. Keywords: Hydrogel template; Microfabrication; Microparticle;
Homogeneous size; Drug delivery”
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