PolySciTech (www.polyscitech.com) latest product is
PolyVivo AK88 (PLGA-PEG-PLGA 1600-1500-1600 3:1 La:Ga) which is a triblock
copolymer that optimally thermogels at 37°C as a 20% w/v solution. Recently similar thermogels were used as a
biomaterial to aid endoscopic submucosal dissection as a cushion to reduce
perforation and other problems associated with this surgical procedure. Read
more: Yu, Lin, Wei Xu, Wenjia Shen, Luping Cao, Yan Liu, Zhaoshen Li, and
Jiandong Ding. "Poly (lactic acid-co-glycolic acid)–poly (ethylene
glycol)–poly (lactic acid- co-glycolic acid) thermogel as a novel submucosal
cushion for endoscopic submucosal dissection." Acta biomaterialia 10, no.
3 (2014): 1251-1258. http://www.sciencedirect.com/science/article/pii/S174270611300603X
“Abstract: Endoscopic submucosal
dissection (ESD) is a clinical therapy for early stage neoplastic lesions in
the gastrointestinal tract. It is, however, faced with a crucial problem: the
high occurrence of perforation. The formation of a submucosal fluid cushion (SFC)
via a fluid injection is the best way to avoid perforation, and thus an
appropriate biomaterial is vital for this minimally invasive endoscopic
technique. In this study, we introduced an injectable thermogel as a novel
submucosal injection substance in ESD. The hydrogel synthesized by us was
composed of poly(lactic acid-co-glycolic acid)–poly(ethylene
glycol)–poly(lactic acid-co-glycolic acid) (PLGA–PEG–PLGA) triblock copolymers.
The polymer/water system was a low-viscosity fluid at room temperature and thus
easily injected, and turned into a non-flowing gel at body temperature after
injection. The submucosal injection of the thermogel to create SFCs was
performed in both resected porcine stomachs and living minipigs. High mucosal
elevation with a clear margin was maintained for a long duration. Accurate en
bloc resection was achieved with the assistance of the thermogel. The mean
procedure time was strikingly reduced. Meanwhile, no obvious bleeding,
perforation and tissue damage were observed. The application of the thermogel
not only facilitated the ESD procedure, but also increased the efficacy and
safety of ESD. Therefore, the PLGA–PEG–PLGA thermogel provides an excellent
submucosal injection system, and has great potential to improve the ESD
technique significantly. Keywords: Endoscopic submucosal dissection (ESD);
Submucosal injection; Biodegradable thermogel; Perforation; Mucosal elevation"
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