PolySciTech (www.polyscitech.com) provides block copolymers
of 5-benzyloxy-trimethylene carbonate (e.g. Polyvivo AK78). This polymer has an inherent benefit of added
hydrophobicity from the benzyloxy unit however there is another usage of this
material. The Benzyloxy unit acts as a leaving group and can be readily removed
by reacting the polymer with hydrogen gas using palladium on carbon catalyst.
This leaves a pendant hydroxyl available for a wide array of further conjugation
reactions. An example of the usage of this and chemical details for a similar
polymer can be seen here: Xie, Zhigang, Huili Guan, Changhai Lü, Xuesi Chen,
and Xiabin Jing. "Synthesis and characterization of novel biotinylated
biodegradable poly (ethylene glycol)- b-poly (carbonate-lactic acid)
copolymers." Acta biomaterialia 1, no. 6 (2005): 635-641. http://www.sciencedirect.com/science/article/pii/S1742706105001121
Blog dedicated to answering technical questions in an open format relating to PolySciTech (A division of Akina, Inc.) products.
Tuesday, June 24, 2014
mPEG-P(5BZTMC) as pendant precursor for pro-drug conjugation
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment