PolySciTech (
www.polyscitech.com) provides a wide
array of both standard block copolymers (Polyvivo AK series) as well as those
with a reactive functional endcap (Polyvivo AI series). Recently these types of polymers were used to
create a dual targeted nanoparticle for treating glioblastoma multiforme (brain
cancer) by functionalizing the particles with interleukin-13 and RGD peptides.
Read more: Gao, Huile, Zhi Yang, Shijie Cao, Yang Xiong, Shuang Zhang, Zhiqing
Pang, and Xinguo Jiang. "Tumor cells and neovasculature dual targeting
delivery for glioblastoma treatment." Biomaterials 35, no. 7 (2014):
2374-2382. http://www.sciencedirect.com/science/article/pii/S0142961213014427
“Abstract: Glioblastoma multiforme (GBM), one of
the most common primary malignant brain tumors, was characterized by
angiogenesis and tumor cells proliferation. Antiangiogenesis and antitumor
combination treatment gained much attention because of the potency in dual
inhibition of both the tumor proliferation and the tumor invasion. In this
study, a neovasculature and tumor cell dual targeting delivery system was
developed through modification of nanoparticles with interleukin-13 peptide and
RGD (IRNPs), in which interleukin-13 peptide was targeting GBM cells and RGD
was targeting neovasculature. To evaluate the potency in GBM treatment,
docetaxel was loaded into IRNPs. In vitro, interleukin-13 peptide and RGD could
enhance the corresponding cells (C6 and human umbilical vein endothelial cells)
uptake and cytotoxicity. In combination, IRNPs showed high uptake in both cells
and increased the cytotoxicity on both cells. In vivo, IRNPs could effectively
deliver cargoes to GBM with higher intensity than mono-modified nanoparticles.
Correspondingly, docetaxel-IRNPs displayed best anti-tumor effect with a median
survival time of 35 days, which was significantly longer than that of
mono-modified and unmodified nanoparticles. Importantly, treatment with
docetaxel-IRNPs could avoid the accumulation of HIF1α in GBM site, which was
crucial for the tumor invasion. After the treatment, there was no obvious
change in normal organs of mice. Keywords: Glioblastoma; Antiangiogenesis;
Anti-tumor therapy; Dual targeting delivery”
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