Thursday, July 17, 2014

mPEG-CPLA for intracellular RNA/DNA delivery

PolySciTech (www.polyscitech.com) provides Methoxy Poly(ethylene glycol)-b-poly(lactide-co-allyl lactide-co-thiolene conjugated diethylaminoethyl-lactide) (mPEG-CPLA, PolyVivo AI 74) which is precursor agent to crosslinked miniemulsions recently used for RNA/DNA delivery. Read more: Zou, Jiong, Chyi Chin Hew, Efrosyni Themistou, Yukun Li, Chih,Kuang Chen, Paschalis Alexandridis, and Chong Cheng. "Clicking Well Defined Biodegradable Nanoparticles and Nanocapsules by UV Induced Thiol Ene CrossLinking in Transparent Miniemulsions." Advanced Materials 23, no. 37 (2011): 4274-4277. http://onlinelibrary.wiley.com/doi/10.1002/adma.201101646/full

“A novel approach for the preparation of nanomaterials is developed by tuning miniemulsion reaction systems to be transparent in order to enable highly efficient photoreactions. Biodegradable nanoparticles and nanocapsules are obtained by UV-induced thiol-ene cross-linking of polylactide (PLA)-based precursor polymers preassembled in transparent miniemulsions. These well-defined nanomaterials may potentially serve as ideal scaffolds for drug delivery.”

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