PolySciTech (www.polyscitech.com) provides a wide
variety of mPEG-PLA copolymers for drug delivery in the polyvivo brand line.
Recently these types of polymers were utilized for the simultaneous delivery of
chemotherapeutic doxorubicin and gemcitabine to tumor cells and the combined
efficacy was observed to be synergistic indicating a potential for this system
to improve cancer treatment. Read more: Liu, Dechun, Yanbin Chen, Xiaoshan
Feng, Miao Deng, Gangqiang Xie, Jianguang Wang, Like Zhang, Qipeng Liu, and
Pengfei Yuan. "Micellar nanoparticles loaded with gemcitabine and
doxorubicin showed synergistic effect." Colloids and Surfaces B:
Biointerfaces 113 (2014): 158-168. http://www.sciencedirect.com/science/article/pii/S0927776513005158
“Highlights: Gemcitabine and
doxorubicin were separately conjugated to biodegradable polyesters. The two drug
conjugates can be mixed at desirable ratio and self-assembled into micelles
M(Gem/Dox) with both gemcitabine and doxorubicin. M(Gem/Dox) displayed
controlled drug release and synergism in vitro. Abstract: Gemcitabine and
doxorubicin were separately chemically linked to biodegradable polymers to
prepare polymer–gemcitabine and polymer–doxorubicin conjugates. Moreover, the
two conjugates can self-assemble into micelles with both gemcitabine and
doxorubicin. In this way, the two anticancer drugs were combined. The in vitro
MTT assay with these combined drugs showed synergistic effect compared to
single use of each drug.”
No comments:
Post a Comment