Friday, July 18, 2014

mPEG-PLA loaded with gemcitabine and doxorubicin for cancer therapy

PolySciTech (www.polyscitech.com) provides a wide variety of mPEG-PLA copolymers for drug delivery in the polyvivo brand line. Recently these types of polymers were utilized for the simultaneous delivery of chemotherapeutic doxorubicin and gemcitabine to tumor cells and the combined efficacy was observed to be synergistic indicating a potential for this system to improve cancer treatment. Read more: Liu, Dechun, Yanbin Chen, Xiaoshan Feng, Miao Deng, Gangqiang Xie, Jianguang Wang, Like Zhang, Qipeng Liu, and Pengfei Yuan. "Micellar nanoparticles loaded with gemcitabine and doxorubicin showed synergistic effect." Colloids and Surfaces B: Biointerfaces 113 (2014): 158-168. http://www.sciencedirect.com/science/article/pii/S0927776513005158


“Highlights: Gemcitabine and doxorubicin were separately conjugated to biodegradable polyesters. The two drug conjugates can be mixed at desirable ratio and self-assembled into micelles M(Gem/Dox) with both gemcitabine and doxorubicin. M(Gem/Dox) displayed controlled drug release and synergism in vitro. Abstract: Gemcitabine and doxorubicin were separately chemically linked to biodegradable polymers to prepare polymer–gemcitabine and polymer–doxorubicin conjugates. Moreover, the two conjugates can self-assemble into micelles with both gemcitabine and doxorubicin. In this way, the two anticancer drugs were combined. The in vitro MTT assay with these combined drugs showed synergistic effect compared to single use of each drug.”


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