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NOTE: mPEG-PCL (AK036) thermogelation properties vary depending on storage time and also conditions such as warming, etc. which lead to self-crystallization of the PCL chains. This material may work as a thermogel but its performance is unreliable. If the batch you have is not thermogelling dissolve in organic solvent (DCM) and dry off quickly to reset polymer chain configuration.
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PolySciTech (www.polyscitech.com)
provides a variety of mPEG-PCL copolymers such as polyvivo AK01, AK36 and
others. Recently mPEG-PCL polymers were utilized to improve delivery of
docetaxel to prostate cancer. Read more: Jin, Ming-ji, Sheng-jun Piao,
Tie-xiong Jin, Zhe-hu Jin, Xue-zhe Yin, and Zhong-gao Gao. "Improved
anti-tumor efficiency against prostate cancer by docetaxel-loaded PEG-PCL
micelles." Journal of Huazhong University of Science and Technology
[Medical Sciences] 34 (2014): 66-75. http://link.springer.com/article/10.1007/s11596-014-1233-0
“Summary: This study primarily focused on the systematic
assessment of both in vitro and in vivo anti-tumor effects of docetaxel-loaded
polyethylene glycol (PEG)2000-polycaprolactone (PCL)2600 micelles on
hormone-refractory prostate cancer (HRPC). By using solvent evaporation method,
PEG-PCL was chosen to prepare doxetaxel (DTX)-loaded mPEG-PCL micelles
(DTX-PMs), with the purpose of eliminating side effects of the commercial
formulation (Tween 80) and prolonging the blood circulation time. The prepared
DTX-PMs had an average particle size of 25.19±2.36 nm, a zeta potential of
0.64±0.15 mV, a polydispersity index of 0.56±0.03, a drug loading of
(8.72±1.05)%, and an encapsulation efficiency of (98.1±8.4)%. In vitro
cytotoxicity studies indicated that DTX-PMs could effectively kill LNCap-C4-2B
cells and show a dose- and time-dependent efficacy. The hemolysis test showed
that DTX-PMs had less hemocytolysis than the commercial product of Duopafei®. A
sustained in vitro release behavior and prolonged circulation time in blood
vessels were observed in the DTX-PMs. Furthermore, when compared with
Duopafei®, the DTX-PMs dramatically reduced the prostate specific antigen (PSA)
level and tumor growth of prostate tumor-bearing nude mice in vivo. In
conclusion, the DTX-PMs can lower systemic side effects, improve anti-tumor
activity with prolonged blood circulation time, and will bring an alternative
to patients with HRPC.”
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