PolySciTech (
www.polyscitech.com)
provides a wide variety of biodegradable PLGA polymers. Recent studies have
paired PLGA porous sheets along with stem cells and tested these in joints of
rabbits. It was found that the combination of PLGA/stem cells improved healing
in these joints. Read more: Qi, Yiying, Yi Du, Weixu Li, Xuesong Dai, Tengfei
Zhao, and Weiqi Yan. "Cartilage repair using mesenchymal stem cell (MSC)
sheet and MSCs-loaded bilayer PLGA scaffold in a rabbit model." Knee
Surgery, Sports Traumatology, Arthroscopy 22, no. 6 (2014): 1424-1433. http://link.springer.com/article/10.1007/s00167-012-2256-3
“Abstract: Purpose: The integration of
regenerated cartilage with surrounding native cartilage is a major challenge
for the success of cartilage tissue-engineering strategies. The purpose of this
study is to investigate whether incorporation of the power of mesenchymal stem
cell (MSC) sheet to MSCs-loaded bilayer poly-(lactic-co-glycolic acid) (PLGA)
scaffolds can improve the integration and repair of cartilage defects in a
rabbit model. Methods: Rabbit bone marrow-derived MSCs were cultured and formed
cell sheet. Full-thickness cylindrical osteochondral defects (4 mm in diameter,
3 mm in depth) were created in the patellar groove of 18 New Zealand white
rabbits and the osteochondral defects were treated with PLGA scaffold (n = 6),
PLGA/MSCs (n = 6) or MSC sheet-encapsulated PLGA/MSCs (n = 6). After 6 and 12
weeks, the integration and tissue response were evaluated histologically. Results:
The MSC sheet-encapsulated PLGA/MCSs group showed significantly more amounts of
hyaline cartilage and higher histological scores than PLGA/MSCs group and PLGA
group (P < 0.05). In addition, the MSC sheet-encapsulated PLGA/MCSs group
showed the best integration between the repaired cartilage and surrounding
normal cartilage and subchondral bone compared to other two groups. Conclusions:
The novel method of incorporation of MSC sheet to PLGA/MCSs could enhance the
ability of cartilage regeneration and integration between repair cartilage and
the surrounding cartilage. Transplantation of autologous MSC sheet combined
with traditional strategies or cartilage debris might provide therapeutic
opportunities for improving cartilage regeneration and integration in humans.”
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