Friday, September 5, 2014

New PLGA-PEG-azide/bromoacetamide/iodoacetamide products from PolySciTech for custom ligand conjugation

PolySciTech (www.polyscitech.com) provides a wide variety of block copolymers as well as reactive intermediates.  A variety of new intermediates are now available from PolySciTech based on the PLGA-PEG diblock configuration and possessing a variety of reactive endcaps including iodoacetamide (PolyVivo AI83), bromoacetamide (PolyVivo AI84), and azide (PolyVivo AI85). Read more about the conjugation chemistry which can be used to couple these to ligands here: Roberts, M. J., M. D. Bentley, and J. M. Harris. "Chemistry for peptide and protein PEGylation." Advanced drug delivery reviews 54, no. 4 (2002): 459-476. Full-Text: http://www.creativepegworks.com/chemistry_for_peptide_and_protein_pegylation.pdf

“Abstract: Poly(ethylene glycol) (PEG) is a highly investigated polymer for the covalent modification of biological macromolecules and surfaces for many pharmaceutical and biotechnical applications. In the modification of biological macromolecules, peptides and proteins are of extreme importance. Reasons for PEGylation (i.e. the covalent attachment of PEG) of peptides and proteins are numerous and include shielding of antigenic and immunogenic epitopes, shielding receptor-mediated uptake by the reticuloendothelial system (RES), and preventing recognition and degradation by proteolytic enzymes. PEG conjugation also increases the apparent size of the polypeptide, thus reducing the renal filtration and altering biodistribution. An important aspect of PEGylation is the incorporation of various PEG functional groups that are used to attach the PEG to the peptide or protein. In this paper, we review PEG chemistry and methods of preparation with a particular focus on new (second-generation) PEG derivatives, reversible conjugation and PEG structures. Keywords PEGylation; PEG-protein; PEG conjugation; PEG chemistry”



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