Wednesday, November 12, 2014

Polymers from Polyscitech used to develop ABT-737/camptothecin co-delivery system to treat colorectal cancer

Recent research using polymers from (PolyVivo AK10) have found that encapsulation of chemotherapeutic agents ABT-737 and camptothecin reduces their side effects as well as induces higher cancer cell aptoposis. Read more:  Schmid, D., G. E. Jarvis, F. Fay, D. M. Small, M. K. Greene, J. Majkut, S. Spence et al. "Nanoencapsulation of ABT-737 and camptothecin enhances their clinical potential through synergistic antitumor effects and reduction of systemic toxicity." Cell death & disease 5, no. 10 (2014): e1454.

“Abstract: The simultaneous delivery of multiple cancer drugs in combination therapies to achieve optimal therapeutic effects in patients can be challenging. This study investigated whether co-encapsulation of the BH3-mimetic ABT-737 and the topoisomerase I inhibitor camptothecin (CPT) in PEGylated polymeric nanoparticles (NPs) was a viable strategy for overcoming their clinical limitations and to deliver both compounds at optimal ratios. We found that thrombocytopenia induced by exposure to ABT-737 was diminished through its encapsulation in NPs. Similarly, CPT-associated leukopenia and gastrointestinal toxicity were reduced compared with the administration of free CPT. In addition to the reduction of dose-limiting side effects, the co-encapsulation of both anticancer compounds in a single NP produced synergistic induction of apoptosis in both in vitro and in vivo colorectal cancer models. This strategy may widen the therapeutic window of these and other drugs and may enhance the clinical efficacy of synergistic drug combinations.”
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