3D tumor spheroids more accurate model for cancer research than conventional 2D
In addition to
polymer products, Akina, Inc. also offers thermogelling matrices for growth of
cells in 3-dimensional structures under the brand-name 3DCellMaker (www.3dcellmaker.com). 3D tumor models
present many advantages over 2D models in that they accurately represent
in-vivo cancer conditions such as microenvironment parameters and cell-cell
interactions. This makes these models more reliable in terms of predicting
whether a therapeutic strategy will actually be effective in the clinic. Read
more: Fitzgerald, Kathleen A., Meenakshi Malhotra, Caroline M. Curtin, Fergal
J. O'Brien, and Caitriona M. O'Driscoll. "Life in 3D is never flat: 3D
models to optimise drug delivery." Journal of Controlled Release 215
(2015): 39-54. http://www.sciencedirect.com/science/article/pii/S016836591530033X
“Abstract:
The development of safe, effective and patient-acceptable drug products is an
expensive and lengthy process and the risk of failure at different stages of
the development life-cycle is high. Improved biopharmaceutical tools which are
robust, easy to use and accurately predict the in vivo response are urgently
required to help address these issues. In this review the advantages and
challenges of in vitro 3D versus 2D cell culture models will be discussed in
terms of evaluating new drug products at the pre-clinical development stage.
Examples of models with a 3D architecture including scaffolds, cell-derived
matrices, multicellular spheroids and biochips will be described. The ability
to simulate the microenvironment of tumours and vital organs including the
liver, kidney, heart and intestine which have major impact on drug absorption,
distribution, metabolism and toxicity will be evaluated. Examples of the
application of 3D models including a role in formulation development, pharmacokinetic
profiling and toxicity testing will be critically assessed. Although
utilisation of 3D cell culture models in the field of drug delivery is still in
its infancy, the area is attracting high levels of interest and is likely to
become a significant in vitro tool to assist in drug product development thus
reducing the requirement for unnecessary animal studies. Keywords: 3D cell
culture; In vitro biopharmaceutical tool; Drug delivery; Biomaterials; The 3 Rs”
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