mPEG-PLA used for gemcitabine-resistant pancreatic cancer treatment
PolySciTech (www.polyscitech.com) provides a wide
array of biodegradable block copolymers including mPEG-PLA which can be used as
a delivery system for a wide variety of therapeutic compounds. Recently this
polymer has been found to assist in the delivery of salinomycin to pancreatic
cancer cells leading to significantly increased cell-death. Read more: Daman,
Zahra, Hamed Montazeri, Masoumeh Azizi, Faegheh Rezaie, Seyed Nasser Ostad,
Mohsen Amini, and Kambiz Gilani. "Polymeric Micelles of PEG-PLA Copolymer
as a Carrier for Salinomycin Against Gemcitabine-Resistant Pancreatic
Cancer." Pharmaceutical research (2015): 1-12. http://link.springer.com/article/10.1007/s11095-015-1737-8
“ABSTRACT:
Purpose: Resistance to gemcitabine in pancreatic cancer (PC) may account for
the failure of conventional treatments. Recently, salinomycin (SAL) has been
identified as selective inhibitor of cancer stem cells (CSCs). In our study, we
aimed to deliver SAL to gemcitabine-resistant PC by the aid of poly ethylene
glycol-b-poly lactic acid (PEG-b-PLA) polymeric micelles (PMs). Methods: SAL-loaded
PMs were prepared and investigated in terms of pharmaceutical properties. MTT
and Annexin V/PI assays were used to study cell proliferation and apoptosis in
AsPC-1 cells in response to treatment with SAL micellar formulations.
Alterations in CSC phenotype, invasion strength, and mRNA expression of
epithelial mesenchymal transition (EMT) markers were also determined in the
treated cells. In vivo antitumor study was performed in Balb/c AsPC-1 xenograft
mice. Results: PM formulations of SAL were prepared in suitable size and
loading traits. In gemcitabine-resistant AsPC-1 cells, SAL was found to
significantly increase cell mortality and apoptosis. It was also observed that
SAL micellar formulations inhibited invasion and harnessed EMT in spite of
induced expression of Snail. The in vivo antitumor experiment showed
significant tumor eradication and the highest survival probability in mice
treated with SAL PMs. Conclusions: The obtained results showed the efficacy of
SAL nano-formulation against PC tumor cells. KEY WORDS: cancer stem cells
epithelial mesenchymal transition pancreatic cancer polymeric micelles
salinomycin”
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