PolySciTech (www.polyscitech.com)
provides a wide array of biodegradable block copolymers including fluorescently
conjugated block copolymers. These types of polymers are particularly useful
for researchers who are performing studies where visualizing and tracking the
polymer is of value. Most notably, this is particularly useful for
nanoparticles since they are small and difficult to see under a microscope.
With a fluorescent dye conjugated onto the polymer, tracking nanoparticle
formulations made of these materials is an easy way to confirm valuable parameters
relevant to targeted delivery such as accumulation and cellular uptake. These new
polymers are available online as PolyVivo AV19, AV20, and AV21 (https://akinainc.com/polyscitech/products/polyvivo/sequential.php#PolymerVisualization).
Similar, lab-made, polymers have been used previously to track nanoparticles
and you can read about this usage here: Wang, Hai, Ying Zhao, Yan Wu, Yu-lin
Hu, Kaihui Nan, Guangjun Nie, and Hao Chen. "Enhanced anti-tumor efficacy
by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA
copolymer nanoparticles." Biomaterials 32, no. 32 (2011): 8281-8290. http://www.sciencedirect.com/science/article/pii/S0142961211008039
No comments:
Post a Comment