PolySciTech PLGA used for anti-HIV drug delivery by electrospun scaffold
PolySciTech (www.polyscitech.com) provides a wide
array of biodegradable polymer products including PLGA. Recently, researchers
at the University of Washington have focused their efforts on generating an
electrospun scaffold for the delivery of anti-HIV medicines using PolySciTech
PLGA (PolyVivo AP060). These meshes can be used for a variety of applications
including vaginal anti-HIV medicinal delivery for treatment and prevention. By
varying the blend of PLGA with another biodegradable polyester, PCL, the research
group was able to control the release rate of the medicines. Read more: Carson,
Daniel, Yonghou Jiang, and Kim A. Woodrow. "Tunable Release of Multiclass
Anti-HIV Drugs that are Water-Soluble and Loaded at High Drug Content in
Polyester Blended Electrospun Fibers." Pharmaceutical Research (2015):
1-12. http://link.springer.com/article/10.1007/s11095-015-1769-0
“Abstract:
Objectives: Sustained release of small molecule hydrophilic drugs at high doses
remains difficult to achieve from electrospun fibers and limits their use in
clinical applications. Here we investigate tunable release of several
water-soluble anti-HIV drugs from electrospun fibers fabricated with blends of
two biodegradable polyesters. Methods: Drug-loaded fibers were fabricated by
electrospinning ratios of PCL and PLGA. Fiber morphology was imaged by SEM, and
DSC was used to measure thermal properties. HPLC was used to measure drug
loading and release from fibers. Cytotoxicity and antiviral activity of
drug-loaded fibers were measured in an in vitro cell culture assay. Results: We
show programmable release of hydrophilic antiretroviral drugs loaded up to 40
wt%. Incremental tuning of highly-loaded drug fibers within 24 h or >30 days
was achieved by controlling the ratio of PCL and PLGA. Fiber compositions
containing higher PCL content yielded greater burst release whereas fibers with
higher PLGA content resulted in greater sustained release kinetics. We also
demonstrated that our drug-loaded fibers are safe and can sustain inhibition of
HIV in vitro. Conclusions: These data suggest that we were able to overcome
current limitations associated with sustained release of small molecule
hydrophilic drugs at clinically relevant doses. We expect that our system
represents an effective strategy to sustain delivery of water-soluble molecules
that will benefit a variety of biomedical applications.”
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