PolySciTech
division of Akina, Inc. (www.polyscitech.com)
provides a wide array of biodegradable block copolymers and specialty polymers.
One of the PolyVivo polymer categories is fluorescently conjugated PLGAs. These
are useful for co-formulation with PLGA nanoparticles so that the nanoparticle
system, as a whole, is fluorescent. Unlike
loose dye, the conjugated fluorescent-PLGA is entrapped in the nanoparticle and
follows it wherever it goes without leaching away. This allows the
nanoparticles to be observed under a fluorescent microscope or other fluorescent
imaging system so that their motion can be tracked. Recently, researchers at
Purdue University utilized PolyVivo AV001 (PLGA-fluorescein 7kDa) to track
PLGA-chitosan nanoparticles as part of a system to deliver chemotherapeutic
paclitaxel. Read more: Abouelmagd,
Sara A., Youn Jin Ku, and Yoon Yeo. "Low molecular weight chitosan-coated
polymeric nanoparticles for sustained and pH-sensitive delivery of
paclitaxel." Journal of drug targeting 23,
no. 7-8 (2015): 725-735. http://www.tandfonline.com/doi/abs/10.3109/1061186X.2015.1054829
Blog dedicated to answering technical questions in an open format relating to PolySciTech (A division of Akina, Inc.) products.
Tuesday, October 20, 2015
PolySciTech PLGA-Fluorescein (AV001) used in investigation of PLGA-Chitosan based paclitaxel delivery system
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