PLLA from PolySciTech used for bone scaffold application research
PolySciTech
division of Akina, Inc (www.polyscitech.com)
provides a wide array of biodegradable polymers including poly(L)lactide
(PLLA). This is a highly crystalline and mechanically strong polymer which has
good properties for load-bearing applications such as bone scaffolds. Recently,
researchers combined PLLA from Polyscitech with hydroxyapatite to form a
conventional bone-scaffold and tested against a novel N-methyldiethanolamine/poly(1,8-octanediol
citrate) based scaffold. Read more: Tang, Jiajun, Jinshan Guo, Zhen Li, Cheng
Yang, Denghui Xie, Jian Chen, Shengfa Li et al. "A fast degradable
citrate-based bone scaffold promotes spinal fusion." Journal of Materials
Chemistry B 3, no. 27 (2015): 5569-5576. http://pubs.rsc.org/en/content/articlehtml/2015/tb/c5tb00607d
“Abstract:
It is well known that high rates of fusion failure and pseudoarthrosis
development (5–35%) are concomitant in spinal fusion surgery, which was
ascribed to the shortage of suitable materials for bone regeneration. Citrate
was recently recognized to play an indispensable role in enhancing
osteoconductivity and osteoinductivity, and promoting bone formation. To
address the material challenges in spinal fusion surgery, we have synthesized
mechanically robust and fast degrading citrate-based polymers by incorporating
N-methyldiethanolamine (MDEA) into clickable poly(1,8-octanediol citrates)
(POC-click), referred to as POC-M-click. The obtained POC-M-click were
fabricated into POC-M-click–HA matchstick scaffolds by forming composites with
hydroxyapatite (HA) for interbody spinal fusion in a rabbit model. Spinal
fusion was analyzed by radiography, manual palpation, biomechanical testing,
and histological evaluation. At 4 and 8 weeks post surgery, POC-M-click–HA
scaffolds showed optimal degradation rates that facilitated faster new bone
formation and higher spinal fusion rates (11.2 ± 3.7, 80 ± 4.5 at week 4 and 8,
respectively) than the poly(L-lactic acid)–HA (PLLA–HA) control group (9.3 ±
2.4 and 71.1 ± 4.4) (p < 0.05). The POC-M-click–HA scaffold-fused
vertebrates possessed a maximum load and stiffness of 880.8 ± 14.5 N and 843.2
± 22.4 N mm−1, respectively, which were also much higher than those of the
PLLA–HA group (maximum: 712.0 ± 37.5 N, stiffness: 622.5 ± 28.4 N mm−1, p <
0.05). Overall, the results suggest that POC-M-click–HA scaffolds could
potentially serve as promising bone grafts for spinal fusion applications.”
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