Monday, August 8, 2016

PLGA from PolySciTech used for development of nanoparticle stability model to prevent lethal clogs in blood-stream

PolySciTech division of Akina, Inc (www.polyscitech.com) provides a wide array of biodegradable polymers including PLGA. Recently, PLGA from PolySciTech (PolyVivo AP082) was used to generate model nanoparticles for validating a system developed to determine nanoparticle colloidal stability. This research allows for a tool which ensures nanoparticles will not collect up and clog in a biological system thus improving the safety of using nanoparticles to deliver medicines. Read more: Shaikh, Muhammad Vaseem, Manika Kala, and Manish Nivsarkar. "Development and Optimization of an Ex Vivo Colloidal Stability Model for Nanoformulations." AAPS PharmSciTech: 1-5. http://link.springer.com/article/10.1208/s12249-016-0597-9


“Abstract: Nanotechnology is having a significant impact in the drug delivery systems and diagnostic devices. As most of the nanosystems are intended to be administered in vivo, there is a need for stability models, which could simulate the biological environment. Instability issues could lead to particle aggregation and in turn could affect the release of the drug from the nanosystems and even lead to clogging of the systemic blood circulation leading to life-threatening situation. We have developed an ex vivo colloidal stability model for testing the stability of nanosystems over a period of 48 h, which is the typical residence time of the nanoparticles in vivo. Tissue homogenates of rat spleen, brain, kidney, and liver were stabilized and optimized for the study; additionally, plasma and serum were used for the same. Poly (lactide-co-glycolic acid) nanoparticles were used as model nanosystem, and no significant change was found in the size and polydispersity index of the nanoparticles in the biological solutions. Moreover, no change in morphology was observed after 48 h as observed by TEM microscopy. Hence, the developed model could prevent the failure of the developed nanosystem during clinical and preclinical application by serving as an initial checkpoint to study their interaction with the complex milieu. Keywords:ex vivo colloidal stability PLGA nanoparticle nanosystem”
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