Wednesday, September 28, 2016

Thermogelling vinyl-reactive products now available and a new TechSite SmallWorld


PolySciTech division of Akina, Inc. (www.polyscitech.com) provides a wide variety of biodegradable polymers. A new tech-site: SmallWorld (www.nanopoop.com) covering microparticle and nanoparticle synthesis is up. Our latest product offerings include acrylate activated thermogelling materials which allow for photo-curing or other reactions. These include Poloxamer 407 diacrylate (PolyVivo AI146) and hydrophobically modified cellulose acrylate (PolyVivo AI147). Recently, a material similar to PolyVivo AI146 was utilized as part of biocompatible hydrogel development. Read more: Shachaf, Yonatan, Maya Gonen-Wadmany, and Dror Seliktar. "The biocompatibility of Pluronic® F127 fibrinogen-based hydrogels." Biomaterials 31, no. 10 (2010): 2836-2847. http://www.sciencedirect.com/science/article/pii/S0142961209014379


“Abstract: Our research is focused on the design of hydrogel biomaterials that can be used for 3-D cell encapsulation and tissue engineering. In this study, our goal was to engineer a temperature-responsive biomaterial to possess bioactive properties using polymer and protein chemistry, and at the same time provide the biomaterial with susceptibility to cell-mediated remodeling. Toward this goal, we developed a biomimetic material that can harness the bioactive properties of fibrinogen and the unique structural properties of Pluronic®F127. Pluronic®F127 is a synthetic block copolymer that exhibits reverse thermal gelation (RTG) in response to small changes in ambient temperature. We conjugated fibrinogen to Pluronic®F127 to create a biosynthetic precursor with tunable physicochemical properties based on the relationship between the two constituents. A hydrogel matrix was formed from the fibrinogen-F127 adducts by free-radical polymerization using light activation (photo-polymerization). These materials displayed a reversible temperature-induced physical sol–gel transition and an irreversible light-activated chemical cross-linking. The susceptibility of this hydrogel biomaterial to protease degradation and consequent cell-mediated remodeling was controlled by the Pluronic®F127 constituent. The protein-based material also conveyed inductive signals to cells through bioactive sites on the fibrinogen backbone, as well as through structural properties such as the matrix modulus. We apply these materials as a tissue engineering hydrogel scaffold for 3-D in vitro culture of dermal fibroblasts in order to gain a better understanding of how the material bioactivity and matrix properties can independently affect cell morphology and remodeling. Keywords: Fibrinogen; Fibroblast; Hydrogel; Polyethylene oxide; Pluronic; Scaffold”


Post a Comment