Thursday, September 29, 2016

Thiolated Silica nanoparticles, licensed from University of Reading, now available from PolySciTech

PolySciTech division of Akina, Inc. (www.polyscitech.com) provides a wide array of research supplies. Recently, we have licensed the rights for generation of thiolated nanoparticles as developed in Dr. Khutoryanskiy’s lab. These are now available as PolyVivo AO054 (https://akinainc.com/polyscitech/products/polyvivo/catalogue.php?highlight=AO054#h) These versatile silica-thiol nanoparticles have a wide array of applications. Read more about them in the original publication here: Irmukhametova, Galiya S., Grigoriy A. Mun, and Vitaliy V. Khutoryanskiy. "Thiolated mucoadhesive and PEGylated nonmucoadhesive organosilica nanoparticles from 3-mercaptopropyltrimethoxysilane." Langmuir 27, no. 15 (2011): 9551-9556. http://pubs.acs.org/doi/abs/10.1021/la201385h

“Abstract: A novel approach has been developed to synthesize thiolated sub-100 nm organosilica nanoparticles from 3-mercaptopropyltrimethoxysilane (MPTS) through its self-condensation in dimethylsulfoxide in contact with atmospheric oxygen. The formation of MPTS nanoparticles proceeds through the condensation of methoxysilane groups and simultaneous disulfide bridging caused by partial oxidation of thiol groups. These nanoparticles showed excellent colloidal stability in dilute aqueous dispersions but underwent further self-assembly into chains and necklaces at higher concentrations. They exhibited very good ability to adhere to ocular mucosal surfaces, which can find applications in drug delivery. The thiolated nanoparticles could also be easily modified through PEGylation resulting in a loss of their mucoadhesive properties.”


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