Biodegradable polymers such as PLGA are all alkyl polyesters which undergo hydrolysis to break down into residues and oligomers. The time over which this process occurs varies widely based on the molecular weight and chemical makeup (LA:GA ratio, etc.) of the polymers. Recently, PolySciTech (www.polyscitech.com) concluded a 9-month study on select polymers (AP081, AP086, AP089, AP091, AP120, AP136, AP178, and AP190) tracking their mass loss and molecular weight changes as they degraded in water at 37 ⁰C. The results of this degradation study can be seen on the technical white-paper here (http://akinainc.com/pdf/Whitepaper-polymer-degradation.pdf).
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