PLGA from PolySciTech used in development of cartilage tissue regeneration for arthritis treatment

 

Arthritis is an inflammatory disease that affects about 1 in 5 USA adults (CDC National statistics). The immune system attacks cartilage in the joints which initially causes pain and stiffness but can lead to loss of functionality of the joint. Researchers at Universidade do Porto (Portugal) SINTEF Industry (Norway), Ulm University Medical Center Ulm (Germany), and Askel Healthcare Ltd (Finland) used PLGA from PolySciTech Division of Akina, Inc. (www.polyscitech.com) to develop anti-inflammatory nanoparticles to work with a scaffold system for treatment of arthritis. This research holds promise to improve treatment of this debilitating disease. Read more: Pereira Vasconcelos, Daniela, Catarina Leite Pereira, Marina Couto, Estrela Neto, Beatriz Ribeiro, Filipe Albuquerque, Alexandra Freitas et al. "Nanoenabled Immunomodulatory Scaffolds for Cartilage Tissue Engineering." Advanced Functional Materials (2024): 2400627. https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.202400627

“Articular cartilage regeneration is a challenge in tissue engineering. Although diverse materials have been developed for this purpose, cartilage regeneration remains suboptimal. The integration of nanomaterials into 3D network materials holds great potential in the improvement of key mechanical properties, particularly important for osteochondral replacement scaffolds and even to function as carriers for disease-modifying drugs or other regulatory signals. In this study, a simple yet effective cell-free nanoenabled Col-PLA scaffold specially designed to enhance cartilage regeneration and modulate inflammatory response is proposed, by incorporating poly(lactic-co-glycolic acid) (PLGA) ibuprofen nanoparticles (NPs) into a collagen/polylactide (Col-PLA) matrix. The developed nanoenabled scaffold successfully decreases IL-1β release and leads to primary human chondrocytes survival, ultimately restoring extracellular matrix (ECM) production under inflammatory conditions. The nanoenabled Col-PLA scaffolds secretome effectively decreases macrophage invasion in vitro, as well as neutrophil infiltration and inflammatory mediators’, namely the complement component C5/C5a, C-reactive protein, IL-1β, MMP9, CCL20, and CXCL1/KC production in vivo in a rodent air-pouch model. Overall, the established nanoenabled scaffold has the potential to support chondrogenesis as well as modulate inflammatory response, overcoming the limitations of traditional tissue engineering strategies.”

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