PEG-PLGA from PolySciTech used in development of triple-chemotherapy loaded nanoparticles

 

Cancer is a complex disease often requiring multiple drugs to elicit effective treatment. Researchers at University of Ottawa and University of Toronto used mPEG-PLGA (Cat# AK148) from PolySciTech Division of Akina, Inc. (www.polyscitech.com) to create nanoparticles loaded with cisplatin, olaparib, and metformin for cancer therapy. This research holds promise to improve treatment of cancer. Read more: Durocher, Emma, Sean McGrath, Esha Gahunia, Naomi Matsuura, and Suresh Gadde. "Development of 3-in-1 nanotherapeutic strategies for ovarian cancer." bioRxiv (2024): 2024-07. https://www.biorxiv.org/content/10.1101/2024.07.17.604002.abstract

“Among gynecological cancers, ovarian cancer causes the most fatality. Platin-based chemotherapy is the primary therapeutic option, but it is limited by a variety of drug resistance mechanisms. Ovarian cancer is a complex and challenging disease to treat, and combination approaches have shown stronger efficacy than a single drug alone. However, they still need to overcome challenges, such as the non-selective distribution of drugs, and side effects caused by each drug in the combination. To overcome these issues, here we explored a 3-in-1 combination nanotherapeutic approach containing cisplatin, olaparib, and metformin for ovarian cancer. To encapsulate hydrophilic cisplatin and metformin inside the nanoparticle (NP) core, we developed cisplatin polymer prodrugs and metformin derivatives. Our results showed successful development of 3-in-1 NPs containing cisplatin, olaparib, and metformin, and they are stable in the physiological conditions. In vitro evaluation showed each agent in the 3-in-1 NPs is active and exerts therapeutic effects, contributing to ovarian cancer cell killing at lower concentrations. These results provide insight into developing novel nanotherapeutic strategies for improving ovarian cancer treatment.”

mPEG-PLGA (Cat# AK148): https://akinainc.com/polyscitech/products/polyvivo/index.php?highlight=AK148#h

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Video: https://youtu.be/WcgTeg291Kw