PLA from PolySciTech used in development of inulin-PLA copolymers for drug delivery

 

Inulin, a water-soluble polysaccharide from plants, can be used as a biomaterial for drug delivery and other applications. Researchers at University of Salerno, University of Naples Federico II, and Polish Academy of Sciences used two sizes of PLA (Cat # AP005, AP079) from PolySciTech Division of Akina, Inc. (www.polyscitech.com) to synthesize inulin-PLA. This research holds promise to provide for novel methods of drug delivery. Read more: Sardo, C., G. Auriemma, C. Mazzacano, C. Conte, V. Piccolo, T. Ciaglia, M. Denel-Bobrowska, A. B. Olejniczak, D. Fiore, and M. C. Proto. "Inulin Amphiphilic Copolymer-Based Drug Delivery: Unraveling the Structural Features of Graft Constructs.” Pharmaceutics 2024, 16, 971. https://www.mdpi.com/1999-4923/16/8/971

“In this study, the structural attributes of nanoparticles obtained by a renewable and nonimmunogenic “inulinated” analog of the “pegylated” PLA (PEG-PLA) were examined, together with the potential of these novel nanocarriers in delivering poorly water-soluble drugs. Characterization of INU-PLA assemblies, encompassing critical aggregation concentration (CAC), NMR, DLS, LDE, and SEManalyses, was conducted to elucidate the core/shell architecture of the carriers and in vitro cytoand hemo-compatibility were assayed. The entrapment and in vitro delivery of sorafenib tosylate (ST) were also studied. INU-PLA copolymers exhibit distinctive features: (1) Crew-cut aggregates are formed with coronas of 2–4 nm; (2) a threshold surface density of 1 INU/nm2 triggers a configuration change; (3) INU surface density influences PLA core dynamics, with hydrophilic segment stretching affecting PLA distribution towards the interface. INU-PLA2 NPs demonstrated an outstanding loading of ST and excellent biological profile, with effective internalization and ST delivery to HepG2 cells, yielding a comparable IC50.”

PLA (Cat# AP005): https://akinainc.com/polyscitech/products/polyvivo/index.php?highlight=AP005#h

PLA (Cat# AP079): https://akinainc.com/polyscitech/products/polyvivo/index.php?highlight=AP079#h

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