PolySciTech
provides amine reactive Poly(n-isopropylacrylamide)-n-hydroxysuccinimide
(PNIPAM-NHS) (AI57)
as a thermosensitive reactive intermediate. Similar polymers have been utilized
to generate PNIPAM-trypsin as a thermosensitive enzyme. Ding, Zhongli, Guohua
Chen, and Allan S. Hoffman. "Synthesis and purification of thermally
sensitive oligomer-enzyme conjugates of poly
(N-isopropylacrylamide)-trypsin." Bioconjugate chemistry 7, no. 1 (1996):
121-125. http://pubs.acs.org/doi/abs/10.1021/bc950087r
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