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NOTE: mPEG-PCL (AK036) thermogelation properties vary depending on storage time and also conditions such as warming, etc. which lead to self-crystallization of the PCL chains. This material may work as a thermogel but its performance is unreliable. If the batch you have is not thermogelling dissolve in organic solvent (DCM) and dry off quickly to reset polymer chain configuration.
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PolySciTech
provides thermogelling block copolymers of methoxypoly(ethylene
glycol)-b-polycaprolactone (mPEG-PCL (750-2400Da) (PolyVivo
AK36). Recently similar polymer was utilized to effectively deliver
doxycycline in a mouse model and was shown to effectively treat implanted
cancer cells when used as an injectable drug delivery depot formulation. Kang, Yun Mi, Gyeong Hae Kim, Jae Il
Kim, Da Yeon Kim, Bit Na Lee, So Mi Yoon, Jae Ho Kim, and Moon Suk Kim.
"In vivo efficacy of an intratumorally injected in situ-forming
doxorubicin/poly (ethylene glycol)-b-polycaprolactone diblock copolymer." Biomaterials 32,
no. 20 (2011): 4556-4564. http://www.sciencedirect.com/science/article/pii/S014296121100247X
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