New Product: 5-benzloxy trimethylene carbonate

PolySciTech (www.polyscitech.com) now provides 5-benzyloxy trimethylene carbonate monomer (cat# AM07) for use in ring opening polymerization. Recently this type of monomer has been utilized to generate copolymers with trimethylene carbonate which were found to be biocompatible. Read more: Wang, Xu‐Li, Ren‐Xi Zhuo, Shi‐Wen Huang, Li‐Jian Liu, and Feng He. "Synthesis, Characterization and In Vitro Cytotoxicity of Poly [(5‐benzyloxy‐trimethylene carbonate)‐co‐(trimethylene carbonate)]." Macromolecular Chemistry and Physics 203, no. 7 (2002): 985-990. 

http://onlinelibrary.wiley.com/doi/10.1002/1521-3935(20020401)203:7%3C985::AID-MACP985%3E3.0.CO;2-0/abstract 

 “Abstract: The ring-opening copolymerization of 5-benzyloxy-trimethylene carbonate (BTMC) with trimethylene carbonate (TMC) was described. The polymerization was carried out in bulk at 150°C using stannous octanoate as initiator. The influence of reaction conditions such as polymerization time and initiator concentration on the yield and molecular weight of the copolymers were investigated. The poly(BTMC-co-TMC)s obtained were characterized by FT-IR, 1H NMR, 13C NMR, GPC and DSC. NMR results of copolymer showed no evidence for decarboxylation occurring during the propagation. The relationship between the copolymer glass transition temperature and composition was in agreement with the Fox equation. The in vitro cytotoxicity studies of the poly(BTMC-co-TMC) (50 : 50) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay demonstrated that the copolymer has low cytotoxicity compared to poly[(lactic acid)-co-(glycolic acid)] (75 : 25).”