Arthritis is a debilitating inflammatory disease of
the joints which can damage cartilage and create a considerable amount of pain
as well as loss of function for the patient. Targeted therapy offers hope for
relief to patients from this chronic disease. One means of generating targeted
nanoparticles is to utilize thiol-maleimide reaction to connect peptides to the
exterior of Maleimide-reacting nanoparticles made using Mal-PEG-PLGA. Recently,
Researchers at University of Connecticut and University of Harford utilized
mPEG-PLGA (PolyVivo #AK037) and Maleimide-PEG-PLGA (Polyvivo #AI020) from
PolySciTech (www.polyscitech.com)
to generate a nanoparticle system for treatment of arthritis. This research
holds promise for treating this debilitating disease. Read more: Jiang, Tao,
Ho-Man Kan, Komal Rajpura, Erica J. Carbone, Yingcui Li, and Kevin W-H. Lo.
"Development of Targeted Nanoscale Drug Delivery System for Osteoarthritic
Cartilage Tissue." Journal of Nanoscience and Nanotechnology 18, no. 4
(2018): 2310-2317. http://www.ingentaconnect.com/contentone/asp/jnn/2018/00000018/00000004/art00006
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