Gastric cancer is a very common and deadly form of
cancer which kills about 11,000 people per year in America. Eliminating cancer
stem cells is a key step to treating this form of cancer. Recently, researchers
working at Sichuan University, Guizhuo Provincial People’s Hospital, and Second
Military Medical University (China) utilized PEG-PLGA From PolySciTech (www.polyscitech.com)
to develop nanoparticles loaded with salinomycin, which kills cancer
stem-cells, and docetaxel, a standard chemotherapy agent, for treatment of
gastric cancer. They found this combination in nanoparticles suppressed tumor
growth more effectively than alone or without the nanoparticles. This research
holds promise for treating this common and lethal form of cancer. Read more: Li,
Lan, Dejun Cui, Limin Ye, Yu Li, Liyi Zhu, Lanqun Yang, Banjun Bai, Zhao Nie,
Jie Gao, and Yu Cao. "Codelivery of salinomycin and docetaxel using poly
(D, L-lactic-co-glycolic acid)-poly (ethylene glycol) nanoparticles to target
both gastric cancer cells and cancer stem cells." Anti-Cancer Drugs 28,
no. 9 (2017): 989-1001. http://journals.lww.com/anti-cancerdrugs/Fulltext/2017/10000/Codelivery_of_salinomycin_and_docetaxel_using.6.aspx
“Cancer stem cells (CSCs) in gastric cancer (GC) have
been established recently as key therapeutic targets for the successful
treatment of GC. Emerging evidence suggests that both CSCs and cancer cells
should be eradicated to achieve optimal therapeutic efficacy. In the present
study, salinomycin, which has been reported to kill CSCs, was used in
combination with docetaxel, a chemotherapeutic drug that is used as first-line
therapy in GC, to eradicate both GC stem cells (SCs) and cancer cells.
Salinomycin and docetaxel were loaded separately into
poly(D,L-lactic-co-glycolic acid)-poly(ethylene glycol) nanoparticles of ∼140 nm with a narrow size
distribution, high drug loading, and sustained drug release. GC SCs were
isolated by magnetic-activated cell sorting on the basis of CD44 expression as
the CSC phenotype. CD44+ GC SCs showed the characteristics of CSCs, including
increased SC gene expression, tumorsphere formation capacity, and tumorigenicity
in nude mice. We found that both salinomycin and salinomycin-loaded
nanoparticles (salinomycin-NPs) could selectively eradicate GC SCs, as
reflected by reduced tumorsphere formation capacity and the frequency of CD44+
GC cells, whereas docetaxel and docetaxel-loaded nanoparticles (docetaxel-NPs)
could significantly eradicate GC cells. In nude mice bearing GC xenografts,
salinomycin-NPs and salinomycin significantly decreased the intratumor
population of GC SCs. Notably, salinomycin-NPs combined with docetaxel-NPs
suppressed tumor growth more effectively than did salinomycin combined with
docetaxel, single salinomycin-NPs, or docetaxel-NPs. Therefore, salinomycin-NPs
combined with docetaxel-NPs represent a promising strategy for the treatment of
GC by eradicating both GC SCs and cancer cells.”
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