Tissue engineering is a new field which holds promise to
replace damaged or missing bone, muscle, skin, and even nerve tissue in injured
patients. This technology relies on use of cell-scaffolds to provide mechanical
support to the growing cells, as well as maintain suitable oxygen perfusion,
cell-compatibility, and blood flow. This technology holds amazing potential to
prevent amputations or life-time paralysis in the wake of severe trauma.
However, the exact structure and nature of the cell-scaffold has to be exactly
designed in order for the new-growing tissue to succeed. Recently, researchers
at Chonnam National University (Korea) used PLLA (PolyVivo AP007) from
PolySciTech (www.polyscitech.com) to
develop a novel bone-tissue scaffold with a dedicated perfusion channel to
ensure flow of oxygenated blood to the growing cells. This research holds
promise to provide for repairing or replacing severely damaged bone tissue
without requiring an autograft. Read more: Tan, Shiyi, Jiafei Gu, Seung Chul
Han, Dong-Weon Lee, and Kiju Kang. "Design and fabrication of a
non-clogging scaffold composed of semi-permeable membrane." Materials
& Design 142 (2018): 229-239. https://www.sciencedirect.com/science/article/pii/S0264127518300418
“Highlights: A 3D polymer membrane architecture was proposed
as a novel concept of bio scaffold. It had two sub-volumes that were
intertwined but separated by a semi-permeable membrane. One sub-volume was used
for cell culture, while the other served as a perfusion channel. Mass transfer was
implemented through the interfacial semi-permeable membrane. Despite very high
porosity, its strength & modulus was appropriate for bones or cartilages.
Abstract: In this study, a novel concept of polymer scaffold was proposed based
on 3D porous membrane architecture. It had two distinct sub-volumes intertwined
with each other but separated by a single continuous smooth semi-permeable
membrane. One sub-volume was used for cell culture, while the other served as a
perfusion channel. Mass transfer was implemented through the interfacial porous
membrane. Consequently, this scaffold was expected to be completely free from
clogging problem due to growing tissue. The sample scaffolds of poly l-lactic
acid (PLLA) was fabricated based on 3D UV photo-lithography and porogen
leaching technique, which provided a P-surface-like architecture composed of
porous membrane having smooth and fine texture with considerably high porosity.
Despite high overall porosity of approximately 97%, these scaffolds had
strengths and Young's moduli appropriate for regeneration of bones or
cartilages. Wettability and permeability of polydopamine-coated PLLA porous
membrane were sufficiently high. Keywords: 3D membrane architecture; Minimal
surface; Scaffold; 3D lithography”
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