PLGA From PolySciTech used in the development of photoluminescent nanoparticles for treatment and diagnosis of cardiovascular disease.

The leading cause of death worldwide is cardiovascular disease. Recently, researchers at The University of Texas at Arlington, Pennsylvania State University, VA North Texas Medical Center, and The University of Texas Southwestern Medical Center used PLGA (PolyVivo AP154) from PolySciTech (www.polyscitech.com) as part of developing a nanoparticle based therapy for this disease. This research holds promised for improved therapies against heart disease. Read more: Kuriakose, Aneetta E., Nikhil Pandey, Dingying Shan, Subhash Banerjee, Jian Yang, and Kytai T. Nguyen. "Characterization of Photoluminescent Polylactone-Based Nanoparticles for Their Applications in Cardiovascular Diseases." Frontiers in Bioengineering and Biotechnology 7 (2019). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886382/

“Abstract: Cardiovascular diseases (CVD) affect a large number of the population across the globe and are the leading cause of death worldwide. Nanotechnology-based drug delivery has currently offered novel therapeutic options to treat these diseases, yet combination of both diagnostic and therapeutic abilities is further needed to understand factors and/or mechanisms that affect the treatment in order to design better therapies to challenge CVD. Biodegradable photoluminescent polylactones (BPLPLs) enable to bridge this gap as these materials exhibit a stable, long-term intrinsic fluorescence as well as offers excellent cytocompatibility and biodegradability properties. Herein, we formulated three different BPLPL based nanoparticles (NPs), including BPLP-co-poly (L-lactic acid) (BPLPL-PLLA), BPLP-co-poly (lactic-co-glycolic acid) copolymers with lactic acid and glycolic acid ratios of 75:25 (BPLPL-PLGA75:25) and 50:50 (BPLPL-PLGA50:50), and extensively evaluated their suitability as theranostic nanocarriers for CVD applications. All BPLPL based NPs were <160 2="" accumulation="" activation="" adhesion="" all="" an="" and="" approved="" as="" based="" be="" better="" bioimaging="" biological="" blood="" body="" bplp="" bplpl-based="" bplpl-plga="" bplpl-plla="" bplpl="" br="" cardiovascular="" carriers="" cell="" cells="" cellular="" characteristics="" comparable="" compared="" compatibility="" consisted="" copolymerized="" cvd.="" days.="" deionized="" demonstrated="" depending="" derived="" diagnosis="" disease="" displayed="" dose-dependent="" drug="" effect="" effects="" encapsulated="" endothelial="" excellent="" fda="" fluid="" for="" formulations="" functional="" functions="" furthermore="" had="" have="" hemocompatibility="" hence="" human="" in="" including="" keywords:="" kinetic="" kinetics="" material.="" materials.="" minimal="" model="" nanocarriers="" nitric="" nm="" no="" non-hemolytic="" nps="" of="" on="" our="" over="" overall="" oxide="" photoluminescence="" physical="" platelet="" plga="" polylactones="" potential="" presented="" production.="" profiles="" properties="" protein="" release="" responses="" results="" saline="" serum="" showed="" simulated="" size="" stability="" studies="" such="" superior="" terms="" than="" that="" theranostics="" therapy="" they="" those="" to="" toxicity="" tunable="" umbilical="" utilized="" various="" vascular="" vein="" viability="" vitro="" water="" were="" whole="" with="">
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