PolySciTech (
www.polyscitech.com) provides a wide
array of PLGA-PEG block copolymers. Recently these polymers were found to
increase the delivery of curcumin to lung cells which acted to increase TRF1
expression which reduces cancer cells immortality. Read more: Anganeh, Mortaza Taheri, Fatemeh Sadat
Tabatabaei Mirakabad, Mahmoud Izadi, Vahideh Zeighamian, Fariba Badrzadeh, Roya
Salehi, Nosratollah Zarghami, Masoud Darabi, Abolfazl Akbarzadeh, and Mohammad Rahmati-Yamchi.
"The comparison between effects of free curcumin and curcumin loaded
PLGA-PEG on telomerase and TRF1 expressions in calu-6 lung cancer cell
line." Full Text available here: http://www.innspub.net/wp-content/uploads/2014/05/IJB-V4No10-p134-145.pdf
“Abstract: Lung cancer is the most common cancer
in men still now. Telomerase is responsible for cancerous cells immortality and
is a suitable target for cancer therapy. TRF1 is a modulator for telomerase
activity. It is necessary to find more efficient and safer anticancer drugs.
Curcumin is a natural polyphenol which has many anticancer effects but it has
hydrophobic structure and low solubility in water. PLGA-PEG nanoparticles was
used to comprise effects of free curcumin and curcumin loaded PLGA-PEG on
telomerase and TRF1 expressions in lung cancer cell line. 1H NMR, FT-IR and SEM
confirmed PLGA-PEG structure and curcumin loading on it. Then, cytotoxic
effects of free curcumin and curcumin loaded PLGA-PEG determined by MTT assay.
mRNA expression levels of hTERT and TRF1 was determined by Real-time PCR. MTT
assay data analysis indicated that curcumin cytotoxicity is dose and
time-dependent. Curcumin loaded nanoparticles showed IC50 values in lower
concentration in comparison to free curcumin. Curcumin loaded PLGA-PEG decreased
hTERT expression and increased TRF1 expression more than pure curcumin. Our
study demonstrates curcumin loaded PLGA-PEG promises a natural and efficient
system for anticancer drug delivery to fight lung cancer”
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