PolySciTech (
www.polyscitech.com) provides a variety
of PLGA polymers as well as gold nanoparticles (AO40). Recently researchers
have loaded gold nanoparticles conjugated to PEG into PLGA films creating films
with extended zero order release for glioma treatment. Read more: Dixon, D., B.
J. Meenan, and J. Manson. "PEG Functionalized Gold Nanoparticle Loaded
PLGA Films for Drug Delivery." Journal of Nano Research 27 (2014): 83-94. http://www.scientific.net/JNanoR.27.83
“Abstract: A novel composite of poly (ethylene
glycol) (PEG) functionalized gold nanoparticles (AuNP-PEG) dispersed within
Poly (lactic-go-glycolic) (PLGA) films, were prepared to demonstrate the
concept of a combined targeted and sustained implant material. This technology
offers the promise of improved therapies for difficult to treat tumors such as
Gliomas. Gold nanoparticles (AuNPs) synthesized via a modified Turkevich
method, were functionalized with thiol terminated polyethylene glycol (PEG),
washed using centrifugation, dried, re-suspended in a solution of PLGA in
dichloromethane and finally vacuum dried to produce the solvent cast films. The
degradation and nanoparticle release profile of these films were studied by
immersion in PBS media at 37 °C over periods of up-to 58 days.
Thermogravimetric analysis (TGA), differential scanning calorimetry (DSC),
scanning electron microscopy (SEM) and attenuated total reflectance Fourier
transform infrared spectroscopy (ATR-FTIR) was conducted. The release of the
AuNPs-PEG nanoparticles during degradation was studied using inductively
coupled plasma mass spectroscopy (ICP-MS). It was observed that the AuNP-PEG
nanoparticles were individually dispersed within the PLGA and that their
addition extended the degradation time of the PLGA film, but did not appear to
alter the nature of degradation. The nanoparticle release from the composite
films displayed an approximately zero-order release profile.”
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