PolySciTech (
www.polyscitech.com) provides a wide
array of PLGA and PEG-PLGA type block copolymers. These types of polymers have
been utilized for delivery of microRNAs, which are small non-coding RNA’s that
affect gene expression in cancer cells, for treatement of cancer. A recent
review article provides an excellent overview of this field. Read more: Chen,
Yunching, Dong-Yu Gao, and Leaf Huang. "In Vivo Delivery of miRNAs For
Cancer Therapy: Challenges and Strategies." Advanced drug delivery reviews
(2014). http://www.sciencedirect.com/science/article/pii/S0169409X14001033
“Abstract: MicroRNAs (miRNAs), small non-coding
RNAs, can regulate post-transcriptional gene expressions and silence a broad
set of target genes. miRNAs, aberrantly expressed in cancer cells, play an
important role in modulating gene expressions, thereby regulating downstream
signaling pathways and affecting cancer formation and progression. Oncogenes or
tumor suppressor genes regulated by miRNAs mediate cell cycle progression,
metabolism, cell death, angiogenesis, metastasis and immunosuppression in
cancer. Recently, miRNAs have emerged as therapeutic targets or tools and
biomarkers for diagnosis and therapy monitoring in cancer. Since miRNAs can
regulate multiple cancer-related genes simultaneously, using miRNAs as a
therapeutic approach plays an important role in cancer therapy. However, one of
the major challenges of miRNA-based cancer therapy is to achieve specific,
efficient and safe systemic delivery of therapeutic miRNAs in vivo. This review
discusses the key challenges to the development of the carriers for miRNA-based
therapy and explores current strategies to systemically deliver miRNAs to
cancer without induction of toxicity. Abbreviations: AAVs, adeno-associated
viruses; AEBP1, adipocyte enhancer-binding protein 1; AEG-1, astrocyte elevated
gene-1; Ago, argonaute protein; Ago2, argonaute2 protein; AMOs, anti-miRNA
oligonucleotides; BBB, blood–brain-barrier; CDK6, cyclin-dependent protein
kinase 6; CLL, chronic lymphocytic leukemia; CSC, cancer stem cells; DCs,
dendritic cells; dsRNAs, short double strand RNAs; ECM, extracellular matrix; EGFR,
epidermal growth factor receptor; EMT, epithelial–mesenchymal transition; EPR,
enhanced permeability and retention; FGF, fibroblast growth factor; GBM,
glioblastoma multiforme; HCC, hepatocellular carcinoma; HCV, hepatitis c virus;
HDL, high-density lipoprotein; HIF-α, hypoxia-inducible factor-α; IFN, type I
interferon; IL, interleukin; LAC, lung adenocarcinoma; LNA, locked nucleic
acid; LPH, liposome–polycation–hyaluronic acid; mAbs, monoclonal antibodies;
MCL1, myeloid cell leukemia sequence 1; MDSCs, myeloid-derived suppressor
cells; miRNA, microRNA; NPs, nanoparticles; NSCLC, non-small-cell lung cancer;
PEG, polyethylene glycol; PEI, polyethyleneimine; PLGA,
poly(lactide-co-glycolide); pre-miRNAs, hairpin-forming miRNA precursors;
pri-miRNAs, long RNA primary transcripts; PU, polyurethane; RES,
reticuloendothelial system; RISC, RNA-induced silencing complex; scFv,
single-chain variable fragment; siRNA, short interfering RNA; SLNs, solid lipid
nanoparticles; SNA-NCs, spherical nucleic acid nanoparticle conjugates; SPARC,
secreted protein acidic and rich in cysteine; TLRs, Toll-like receptors; TNF,
tumor necrosis factor; VEGF, vascular endothelial growth factor. Keywords:
miRNA; Gene delivery; In vivo delivery; Cancer therapy; Nanotechnology”
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