PolySciTech (www.polyscitech.com)
provides a wide array of Maleimide-PEG-PLGA and other reactive intermediates.
Recently published PhD thesis of Neda Samadi from Utrecht University utilized
Polyvivo AI20 to generate nanoparticles labelled with 11A4 protein for Her2
targeting and used these nanoparticles to deliver RNAse to tumor cells. Alone
RNAse is innefective at preventing cancer cell growth but when encapsulated in
the delivery system an IC50 of only 5uM was observed. Read more with full-text
available here: Samadi, Neda, Marta M. Kijanka, Sabrina Oliveira, Tina
Vermonden, Cornelus F. van Nostrum, Maryam Amidi, Paul MP van Bergen en
Henegouwen, and W. E. Hennink. "Nanobody-Targeted and RNase-Loaded
Nanoparticles Based on a Hydrophilic Polyester Aimed for Cancer Therapy."
Biodegradable Nanoparticles Based on Aliphatic Polyesters; Towards Targeted
Intracellular Delivery of Protein Therapeutics: 117. http://dspace.library.uu.nl/bitstream/handle/1874/292552/samadi.pdf?sequence=2#page=117
Blog dedicated to answering technical questions in an open format relating to PolySciTech (A division of Akina, Inc.) products.
Wednesday, October 15, 2014
New publication utilizes Mal-PEG-PLGA from PolySciTech for generating Her2 targeted, RNAse delivering, nanoparticle for cancer therapy.
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