PolySciTech (
www.polyscitech.com)
provides a wide array of PLGA and related biodegradable polyesters. Recently
PLGA from PolySciTech was utilized as a control in development of citrate based
bioadhesive. Read more: Xie, Denghui, Jinshan Guo, Reza Mehdizadeh, Richard T.
Tran, Dawei Sun, Guoying Qian, Dadi Jin, Xiaochun Bai, and Jian Yang.
"Development of Injectable Citrate-Based Bioadhesive Bone Implants."
Journal of Materials Chemistry B (2014).
http://pubs.rsc.org/en/content/articlehtml/2014/tb/c4tb01498g
“Abstract: Injectable bone implants have been
widely used in bone tissue repairs including the treatment of comminuted bone
fractures (CBF). However, most injectable bone implants are not suitable for
the treatment of CBF due to their weak tissue adhesion strengths and minimal
osteoinduction. Citrate has been recently reported to promote bone formation
through enhanced bioceramic integration and osteoinductivity. Herein, a novel
injectable citrate-based mussel-inspired bioadhesive hydroxyapatite (iCMBA/HA)
bone substitute was developed for CBF treatment. iCMBA/HA can be set within 2-4
minutes and the as-prepared (wet) iCMBA/HA possess low swelling ratios,
compressive mechanical strengths of up to 3.2±0.27 MPa, complete degradation in
30 days, suitable biocompatibility, and osteoinductivity. This is also the
first time to demonstrate that citrate supplementation in osteogenic medium and
citrate released from iCMBA/HA degradation can promote the mineralization of
osteoblastic committed human mesenchymal stem cells (hMSCs). In vivo evaluation
of iCMBA/HA in a rabbit comminuted radial fracture model showed significantly
increased bone formation with markedly enhanced three-point bending strength
compared to the negative control. Neovascularization and bone ingrowth as well
as highly organized bone formation were also observed showing the potential of
iCMBA/HA in treating CBF.”
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